Coding

Part:BBa_K2171004:Design

Designed by: Slavil Peykov, Desislava Popova   Group: iGEM16_Bulgaria   (2016-10-14)


SAHS2 - osmotic stress protein from tardigrade


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


The "lacI-lacIq and a tac promoter" subpart was amplified from part BBa_K731520 using primers:

F: tatgaattcgcggccgcttctagagTCACTGCCCGCTTTCCAGTC

R: CTAGTACTTTCCTGTGTGACTC


"SAHS2 CDS + transcription terminators" subpart was ordered as gBlock from IDT

Sequence: 

ATATAATTGAATTCGCGGCCGCTTCTAGATGGCAGATGACGCAGCTCACGAGG
AAGGGGTGGAGTGGACGGGTAAGCCGTGGATGGGAAAATGGGAGTCAGATCCT
TCTAAGGATGAGAATGTAGAAGAGTTTAAGAAAAAATTGCAGTTACCTATGTC
CCATTCGGAAATGAACAAGAACTCCAAAGTCTGGATTCACCACTATAAAAAAG
GCGACGAATACCATCATAAGATTATTATCAATGACGCGCATTACAAAAATGAT
ATCGTGTTCAAATTGGGACAAGAGAGTGCCGGGTCGTATAATGGCTCATCATT
CTCCGTGAAATACGAAGACAAAGACGGTGCTTTAGTTGGAAGCGTACACTACA
CGGGTACAAAAGAGCAAAGTCTTGATAAAACCATCAATAATGTATTCAAGCTG
GAGGGCGACCACCTGGTGAAGACGTCCACCATTGAGGGGGTTACCATGAAGCG
CCACTACAACAAACGTCAGTAATAATTGATTAACATCAAATAAAACGAAAGGC
TCAGTCGAAAGACTGGGCCTTTCGTTTTATCTGTTGTTTGTCGGTGAACGCTC
TCTACTAGAGTCACACTGGCTCACCTTCGGGTGGGCCTTTCTGCGTTTATTAC
TAGTAGCGGCCGCTGCAGTTATATAT 


and amplified using primers:

F: gagtcacacaggaaagtactagATGGCAGATGACGCAGCTCAC

R: taactgcagCGGCCGCTACTAGTAATAAACGC


Both subparts were fused together by Overlap Extention PCR. All PCRs were performed with Phusion High Fidelity Polymerase using the standart protocol provided by the manufacturer. The final part was gel purified.The final part was gel purified and cloned in standart vector via restriction (EcoRI and PstI) and ligation.


Note: Uppercase characters in primer sequences correspond to regions that are complementary to the intended matrix. Lowercase characters mark regions of overlap for OEP and/or parts of biobrick regions with restriction sites for EcoRI and PstI.